In Sub-Saharan Africa, there were 215 million Malaria cases and 384,000 malaria deaths recorded in 2019. As the region is home to 94% of the malaria cases worldwide, evidence-based malaria interventions are critical to expand the current intervention paradigms. The Global fund for HIV, TB and Malaria is in the process of developing its post-2022 strategic plan. Therefore, strategic discussions with the Fund need to take into account the regional countries’ context, for a more realistic path to end malaria by 2030. A critical analysis of malaria epidemics in Africa was done to provide evidence-informed recommendations and guidance on how the Global Fund can work with the region to accelerate progress towards malaria elimination.